In non-commercial research in the NHS, costs relating to the study treatment - when they are more than the usual care treatment - are known as Excess Treatment Costs. The principle is that the NHS would fund a study treatment if the study found it effective, so in the research these are paid for by the NHS too. Trusts and other providers have to absorb some of these until they reach a threshold. GP practices, and some other providers, are exempt from this. You can read more about this at https://www.gov.uk/government/publications/excess-treatment-costs-etcs-in-non-commercial-research/excess-treatment-costs-in-non-commercial-research-guidance-for-researchers-funders-and-administrators#provider-thresholds
The Research Delivery Network (RDN) manages national operational oversight of Excess Treatment Costs (ETCs). Our Regional Research Delivery Network (RRDN) manages this process across Yorkshire and Humber, meaning that any applications for ETCs within Yorkshire and Humber should be applied for under this system via the Schedule of Events Cost Attribution Template (SoECAT), liaising with the local AcoRD specialists who can be contacted via the RDN’s study support services. It is the research team's responsibility to apply for the ETC - see here for guidance on how to do this.
The following link provides guidance on how to complete the SoECAT:
When there is an ETC incurred at a general practice, the practice needs to pay out the cost first and it will be reimbursed. ETCs are reimbursed to practices at Q2 if they meet a minimum threshold of £100, or at Q4 if they do not reach the threshold before Q2.
You can read more about ETCs online: https://www.nihr.ac.uk/researchers/collaborations-services-and-support-for-your-research/run-your-study/excess-treatment-costs.htm